Lisa was born in a Muslim family. Her father, who was a great admirer of Mona Lisa's painting, named her Mona. Later he added the name Lisa also. After starting her career with stage dramas and performances, she later went on to star in many acclaimed serials and telefilms.
Lisa made her acting debut in 2003 with the serial, Rabia Zinda Rahegi co-starring with veteran actors such as Talat Hussain, Behroze Sabzwari, Badar Khalil and Ayesha Khan.
Lisa was signed by Bollywood producer, Bhushan Kumar for his film, Kajraare, directed by Pooja Bhatt, and also starring Himesh Reshammiya. The film was shot in Lahore, Dubai and Morocco. The film was released on 15 October 2010.
Lisa is working on her second film Saltanat directed by Syed Faisal Bukhari. She will also do an "item number" for the film and have a important role opposite Ahsan Khan and Javed Sheikh. She also confirmed several Indian actors will be part of the film.